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The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand |
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| Authors: | Dr. Matthew R. Lockett Dr. Heiko Lange Dr. Benjamin Breiten Dr. Annie Heroux Dr. Woody Sherman Dr. Dmitrij Rappoport Patricia O. Yau Dr. Philip W. Snyder Prof. Dr. George M. Whitesides |
| Affiliation: | 1. Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138 (USA);2. Photon Sciences Directorate, Building 745, Brookhaven National Laboratory, Upton, NY 11973 (USA);3. Schr?dinger Inc., 120 West 45thStreet, New York, NY 10036 (USA);4. Wyss Institute for Biologically Inspired Engineering, Harvard University, 60 Oxford Street, Cambridge, MA 02138 (USA) |
| Abstract: | |
| Keywords: | biomolecular recognition carbonic anhydrase hydrophobic effect protein‐ligand binding water |