Direct Amidation from Alcohols and Amines through a Tandem Oxidation Process Catalyzed by Heterogeneous‐Polymer‐Incarcerated Gold Nanoparticles under Aerobic Conditions |
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Authors: | Dr. Jean‐François Soulé Dr. Hiroyuki Miyamura Prof. Dr. Shū Kobayashi |
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Affiliation: | Department of Chemistry, School of Science, The University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo (113‐0033) (Japan), Fax: (+81)?3‐5684‐0634 |
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Abstract: | We describe herein a highly elegant and suitable synthesis of amide products from alcohols and amines through a tandem oxidation process that uses molecular oxygen as a terminal oxidant. Carbon‐black‐stabilized polymer‐incarcerated gold (PICB‐Au) or gold/cobalt (PICB‐Au/Co) nanoparticles were employed as an efficient heterogeneous catalyst depending on alcohol reactivity and generated only water as the major co‐product of the reaction. A wide scope of substrate applicability was shown with 42 examples. The catalysts could be recovered and reused without loss of activity by using a simple operation. |
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Keywords: | alcohols amides heterogeneous catalysis nanoparticles oxidation |
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