CuI/amino acid catalysis in coupling and cyclization of β‐bromo‐α,β‐unsaturated carboxylic acids with terminal alkynes leading to alkylidenefuranones |
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| Authors: | Son Long Ho Chan Sik Cho Heung‐Jin Choi Ho‐Sang Sohn |
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| Affiliation: | 1. Department of Applied Chemistry, Kyungpook National University, , Daegu, 702‐701 South Korea;2. Department of Materials Science and Metallurgical Engineering, Kyungpook National University, , Daegu, 702‐701 South Korea |
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| Abstract: | β‐Bromo‐α,β‐unsaturated carboxylic acids are coupled and cyclized with terminal alkynes in DMF at 110°C in the presence of a catalytic amount of CuI and amino acid along with a base to give alkylidenefuranones in good yields. Similar reaction under microwave irradiation also gave alkylidenefuranones in higher yields. Copyright © 2013 John Wiley & Sons, Ltd. |
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| Keywords: | alkylidenefuranones amino acids β ‐bromo‐α ,β ‐unsaturated carboxylic acids cyclization terminal alkynes |
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