Synthesis of substituted biaryls via Suzuki,Stille and Hiyama cross‐coupling and homo‐coupling reactions by CN‐dimeric and monomeric ortho‐palladated catalysts |
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| Authors: | Abdol R Hajipour Fatemeh Rafiee |
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| Institution: | 1. Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, , Isfahan, 84156 IR, Iran;2. Department of Neuroscience, University of Wisconsin, Medical School, , Madison, WI, 53706‐1532 USA |
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| Abstract: | The catalytic activity of dimeric Pd{C6H2(CH2CH2NH2)–(OMe)2,2,3}(μ‐Br)]2 and monomeric Pd{C6H2(CH2CH2NH2)–(OMe)2,2,3}Br(PPh3)] complexes as efficient, stable and air‐ and moisture‐tolerant catalysts was investigated in the Suzuki, Stille and Hiyama cross‐coupling and homo‐coupling reactions of various aryl halides. Substituted biaryls were produced in excellent yields in short reaction times using catalytic amounts of these complexes. The monomeric complex was demonstrated to be more active than the corresponding dimeric catalyst for the cross‐coupling reaction of unreactive aryl bromides and chlorides. The combination of homogeneous metal catalysts and microwave irradiation gave higher yields of products in shorter reaction times. Copyright © 2013 John Wiley & Sons, Ltd. |
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| Keywords: | palladated catalyst Suzuki reaction Stille reaction Hiyama reaction biaryls |
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