Microwave‐Accelerated Pd‐Catalyzed Desulfitative Direct C2‐Arylation of Free (NH)‐Indoles with Arylsulfinic Acids |
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| Authors: | Tao Miao Pinhua Li Prof. Guan‐Wu Wang Prof. Lei Wang |
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| Affiliation: | 1. Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000 (P.?R. China), Fax: (+86)?561‐3090518;2. Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (P.?R. China);3. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai 200032 (P.?R. China) |
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| Abstract: | The rapid and efficient direct C2‐arylation of free (NH)‐indoles with arylsulfinic acids proceeded through a microwave‐accelerated palladium‐catalyzed desulfitation reaction. By using PdCl2 as a catalyst, silver acetate as an oxidant, and H2SO4 as an additive, arylsulfinic acids with both electron‐donating and electron‐withdrawing groups underwent desulfitative coupling with an array of free (NH)‐indoles, thereby selectively providing C2‐arylindoles in good yields. |
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| Keywords: | arylation desulfitation indoles microwave chemistry palladium |
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