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The Two Faces of Potent Antitumor Duocarmycin‐Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity |
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| Authors: | Tanja Wirth Dr Galina F Pestel Vanessa Ganal Thomas Kirmeier Dr Ingrid Schuberth Theo Rein Professor Lutz F Tietze Professor Stephan A Sieber |
| Institution: | 1. Department Chemie, Center for Integrated Protein Science CIPSM, Institute of Advanced Studies IAS, Technische Universit?t München, Lichtenbergstrasse 4, 85747 Garching (Germany);2. Institute of Organic and Biomolecular Chemistry, Georg‐August‐Universit?t G?ttingen, Tammannstrasse 2, 37033 G?ttingen (Germany);3. Max Planck Institute of Psychiatry, 80804 Munich (Germany) |
| Abstract: | |
| Keywords: | aldehyde dehydrogenase 1 antitumor agents cell biology natural products proteomics |