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Bifunctional Schiff base/Ti(IV) catalysts for enantioselective cyanoformylation of aldehydes with ethyl cyanoformate |
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| Authors: | Nan Ji Lin Yao Wei He Yurong Li |
| Institution: | 1. Department of Chemistry, School of Pharmacy, Fourth Military Medical University, , Xi'an, 710032 People's Republic of China;2. Department of Radiation Medicine, Fourth Military Medical University, , Xi'an, 710032 People's Republic of China |
| Abstract: | A new bifunctional titanium/Schiff base catalyst was developed for the enantioselective cyanoformylation of aldehydes with ethyl cyanoformate. The reaction proceeded smoothly with a mild reaction condition to afford the cyanohydrin ethyl carbonates in high yields (up to 96%) and good enantioselectivities (up to 85% enantiomeric excess). Copyright © 2013 John Wiley & Sons, Ltd. |
| Keywords: | Schiff base asymmetric catalysis titanium cyanoformylation ethyl cyanoformate |