Double Functionalization of Carbon Nanotubes with Purine and Pyrimidine Derivatives |
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| Authors: | Dr Prabhpreet Singh Dr Cécilia Ménard‐Moyon Dr Alessia Battigelli Dr Francesca Maria Toma Dr Jesus Raya Dr Jitendra Kumar Nagapradeep Nidamanuri Prof Sandeep Verma Dr Alberto Bianco |
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| Institution: | 1. CNRS, Institut de Biologie Moléculaire et Cellulaire, Laboratoire d'Immunopathologie et Chimie Thérapeutique, 67000 Strasbourg (France);2. Department of Chemistry, UGC Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143005 PB (India);3. Dipartimento di Scienze Chimiche e Farmaceutiche, Università di Trieste, 34127 Trieste (Italy);4. Laboratoire de RMN et Biophysique des Membranes, CNRS/Université de Strasbourg, 67000 Strasbourg (France);5. Department of Chemistry, Indian Institute of Technology‐Kanpur, Kanpur 208016 UP (India) |
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| Abstract: | Herein, we have developed a synthetic strategy for the covalent double functionalization of single‐walled carbon nanotubes (SWCNTs) with a combination of purine–pyrimidine and purine–purine nucleobase systems. The nucleobases were introduced on the sidewall of oxidized SWCNTs through 1,3‐dipolar cycloaddition and by amidation of the carboxylic acids located at the tips and defect sites of the nanotubes. The new nanohybrids were characterized by transmission electron microscopy, thermogravimetric analysis, FTIR and Raman spectroscopy, magic‐angle spinning NMR spectroscopy, and Kaiser test. The nucleobase/SWCNT conjugates can be envisaged for the modulation of the interactions with nucleic acids by means of base pairing, thereby opening new possibilities in the development of DNA/CNT nanobioconjugates. |
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| Keywords: | carbon nanotubes functionalization nanostructures nucleobases self‐assembly |
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