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Stereoselective Synthesis of Highly Functionalized Nitrocyclopropanes through the Organocatalyic Michael‐Addition‐Initiated Cyclization of Bromonitromethane and β,γ‐Unsaturated α‐Ketoesters |
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| Authors: | Haijian Yu Qiaohui Wang Prof. Youming Wang Prof. Haibing Song Prof. Zhenghong Zhou Prof. Chuchi Tang |
| Affiliation: | Institute and State Key Laboratory of Elemento‐Organic Chemistry, Nankai University, Tianjin 300071 (P.?R. China), Fax: (+86)?022‐23503627 |
| Abstract: | A highly diastereo‐ and enantioselective cyclopropanation of β,γ‐unsaturated α‐ketoesters with bromonitromethane has been successfully developed through a domino Michael‐addition/intramolecular‐alkylation strategy. Acceptable yields (up to 89 %) and enantioselectivities (up to 96 % ee) have been obtained. |
| Keywords: | alkylation asymmetric catalysis Michael addition nitrocyclopropanes organocatalysis |