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Inversion of Enantioselectivity of a Mononuclear Non‐Heme Iron(II)‐dependent Hydroxylase by Tuning the Interplay of Metal‐Center Geometry and Protein Structure
Authors:Sarah M. Pratter  Cornelia Konstantinovics  Dr. Cristiana M. L. Di Giuro  Prof. Dr. Erich Leitner  Dr. Devesh Kumar  Dr. Sam P. de Visser  Dr. Gideon Grogan  Dr. Grit D. Straganz
Affiliation:1. Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12, 8010 Graz (Austria);2. Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz (Austria);3. Department of Applied Physics, School for Physical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Rae Bareilly Road, Lucknow 226‐025 (India);4. Manchester Institute of Biotechnology and School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester M1 7DN (UK);5. York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5DD (UK)
Abstract:
Keywords:asymmetric catalysis  hydroxylation  metalloenzymes  non‐heme iron  protein design
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