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Inversion of Enantioselectivity of a Mononuclear Non‐Heme Iron(II)‐dependent Hydroxylase by Tuning the Interplay of Metal‐Center Geometry and Protein Structure
Authors:Sarah M Pratter  Cornelia Konstantinovics  Dr Cristiana M L Di Giuro  Prof Dr Erich Leitner  Dr Devesh Kumar  Dr Sam P de Visser  Dr Gideon Grogan  Dr Grit D Straganz
Institution:1. Institute of Biotechnology and Biochemical Engineering, Graz University of Technology, Petersgasse 12, 8010 Graz (Austria);2. Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz (Austria);3. Department of Applied Physics, School for Physical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Rae Bareilly Road, Lucknow 226‐025 (India);4. Manchester Institute of Biotechnology and School of Chemical Engineering and Analytical Science, The University of Manchester, 131 Princess Street, Manchester M1 7DN (UK);5. York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5DD (UK)
Abstract:
Keywords:asymmetric catalysis  hydroxylation  metalloenzymes  non‐heme iron  protein design
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