Asymmetric Ion‐Pairing Catalysis |
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Authors: | Dr. Katrien Brak Prof. Eric N. Jacobsen |
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Affiliation: | Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge MA 02138 (USA) |
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Abstract: | Charged intermediates and reagents are ubiquitous in organic transformations. The interaction of these ionic species with chiral neutral, anionic, or cationic small molecules has emerged as a powerful strategy for catalytic, enantioselective synthesis. This review describes developments in the burgeoning field of asymmetric ion‐pairing catalysis with an emphasis on the insights that have been gleaned into the structural and mechanistic features that contribute to high asymmetric induction. |
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Keywords: | anion‐binding catalysis asymmetric catalysis chiral anions ion pairs phase‐transfer catalysis |
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