Synthesis of Monodisperse Hollow Carbon Nanocapsules by Using Protective Silica Shells |
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| Authors: | Bo Quan Gi‐Eun Nam Prof Hyuck Jae Choi Prof Yuanzhe Piao |
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| Institution: | 1. Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151‐742 (Republic of Korea), Fax: (+82)?31‐8889148;2. Department of Radiology and the Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138‐736 (Republic of Korea);3. Advanced Institutes of Convergence Technology, Suwon‐si 443‐270 (Republic of Korea) |
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| Abstract: | Monodisperse hollow carbon nanocapsules (<200 nm) with mesoporous shells were synthesized by coating their outer shells with silica to prevent aggregation during their high‐temperature annealing. Monodispersed silica nanoparticles were used as starting materials and octadecyltrimethoxysilane (C18TMS) was used as a carbon source to create core–shell nanostructures. These core–shell nanoparticles were coated with silica on their outer shell to form a second shell layer. This outer silica shell prevented aggregation during calcination. The samples were characterized by TEM, SEM, dynamic light scattering (DLS), UV/Vis spectroscopy, and by using the Brunauer–Emmett–Teller (BET) method. The as‐synthesized hollow carbon nanoparticles exhibited a high surface area (1123 m2 g?1) and formed stable dispersions in water after the pegylation process. The drug‐loading and drug‐release properties of these hollow carbon nanocapsules were also investigated. |
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| Keywords: | drug delivery hollow structures nanospheres nanostructures silica |
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