| 亲水作用色谱及其在碱性药物分析中的应用 |
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| 引用本文： | 李瑞萍,黄骏雄.亲水作用色谱及其在碱性药物分析中的应用[J].化学进展,2006,18(11):1508-1513. |
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| 作者姓名： | 李瑞萍 黄骏雄 |
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| 作者单位： | 三峡大学Alan G.MacDiarmid再生能源研究所,宜昌,443002;中国科学院生态环境研究中心,环境化学与生态毒理学重点实验室,北京,100085 |
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| 摘 要： | 亲水作用色谱是采用极性固定相、高含量极性有机溶剂-水相缓冲液为流动相的一种分离技术，它能有效地保留反相色谱中保留弱或不保留的强极性碱性药物。本文综述了以未键合硅胶为固定相的亲水作用色谱分离碱性药物的机理、特点及其应用的最新进展。
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| 关 键 词： | 亲水作用色谱 碱性药物 分离 |
| 文章编号： | 1005-281X（2006）11-1508-06 |
| 收稿时间： | 2006-01 |
| 修稿时间： | 2006-05 |
Hydrophillic Interaction Chromatography and Its Applications in the Separation of Basic Drugs |
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| Li Ruiping,Huang Junxiong.Hydrophillic Interaction Chromatography and Its Applications in the Separation of Basic Drugs[J].Progress in Chemistry,2006,18(11):1508-1513. |
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| Authors: | Li Ruiping Huang Junxiong |
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| Institution: | 1. Alan G. MacDiarmid Research Institute of Renewable Energy, Chinese Three Gorges University, Yichang 443002, China; 2. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China |
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| Abstract: | Hydrophilic interaction chromatography(HILIC) is a convenient method for separating basic drugs and their metabolites which have poor retention on reversed-phase column by passing highly polar organic-aqueous buffer mobile phase across a polar stationary phase.The mechanism and characterization of HILIC using silica column/reversed-phase elution system are described.In addition,the recent progress of its applications in the separation of basic pharmaceuticals is reviewed. |
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| Keywords: | hydrophilic interaction chromatography basic drugs separation |
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