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Room-Temperature Dialkylamination of Chloroheteroarenes Using a Cu(II)/PTABS Catalytic System |
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| Authors: | Harshita Shet Manisha Patel Jyoti M Waikar Dr Pavan M More Dr Yogesh S Sanghvi Dr Anant R Kapdi |
| Institution: | 1. Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai, 400019 India
Department of Chemistry, Institute of Chemical Technology-Indian Oil Odisha Campus, IIT Kharagpur Extension Centre, Mouza Samantpuri, Bhubaneswar, 751013 Odisha, India;2. Department of Chemistry, Institute of Chemical Technology, Nathalal Parekh Road, Matunga, Mumbai, 400019 India;3. Rasayan Inc., 2802 Crystal Ridge road, Encinitas, CA 92024–6615 U.S.A. |
| Abstract: | The dimethylamino functionality has significant importance in industrially relevant molecules and methodologies to install these efficiently are highly desirable. We report herein a highly efficient, room-temperature dimethylamination of chloroheteroarenes performed via the in-situ generation of dimethylamine using N,N-dimethylformamide (DMF) as precursor wiith a large substrate scope that includes various heteroarenes, purines as well as commercially relevant drugs such as altretamine, ampyzine and puromycin precursor. |
| Keywords: | Copper Dialkylamination chloroheteroarenes SNAr amination N N-dimethylformamide (DMF) |