This cover picture describes that MOF-based artificial and semi-artificial photosynthesis systems have been sustainably catalyzing the CO2 reduction, H2 evolution, and other chemical processes upon sun-light irradiation. In such a way, our Earth was successfully protected from pollution and energy crisis due to the depletion of fossil fuels and excessive CO2 emission. More details are discussed in the article by Li et al. on page 335–354.