Diagnostic and therapy-control of inborn metabolic disorders by high-performance liquid chromatography: 2,8-dihydroxyadeninuria,xanthinuria |
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| Authors: | A. Hesse A. Thon A. Classen H. Birwé |
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| Affiliation: | 1. Experimentelle Urologie, Urologische Universit?tsklinik, Sigmund-Freud-Str. 25, D-5300, Bonn 1, FRG
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| Abstract: | Summary 2,8-Dihydroxyadeninuria and xanthinuria are inborn enzyme disorders which must be under lifelong therapeutic control. Quantitative determination of 2,8-DHA and xanthine using reversed phase HPLC was performed. A new application for the separation of purines shortens analysis-time. Examples of the determination of 2,8-DHA and xanthine before and under certain therapies are shown. Long term monitoring of the patients offers the possibility of a reliable prophylaxis against stone recurrence. |
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| Keywords: | Column liquid chromatography Metabolic disorders Xanthine and 2,8-dihydroxyadenine Urine analysis |
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