Determination of ambroxol in an automated multi-pumping pulsed flow system. |
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Authors: | Jo?o L M Santos Arnaud Clausse José L F C Lima M L M F S Saraiva António O S Rangel |
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Institution: | REQUIMTE, Departamento de Química-Fisica, Faculdade de Farmácia, Universidade do Porto, Rua Anibal Cunha 164, 4050-047 Porto, Portugal. joaolms@ff.up.pt |
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Abstract: | A new flow methodology exploiting the multi-pumping approach was developed for the spectrophotometric determination of ambroxol hydrochloride in pharmaceutical preparations. The flow manifold was implemented by using, exclusively, multiple solenoid-actuated micro-pumps, which acted simultaneously as sample insertion, solutions propelling and reagents commutation units. Linear calibration plots were obtained over an ambroxol concentration ranging from 10 to 200 mg l(-1) (r.s.d. < 0.5%, n = 15) and a sampling rate of about 60 samples per hour (flow rate = 1.92 ml min(-1), sample volume = 80 microl). |
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