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One-pot synthesis of 2-trifluoromethylchromones |
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| Authors: | Isabel C Henao Castañeda Sonia E Ulic Carlos O Della Védova Nils Metzler-NolteJorge L Jios |
| Institution: | a Laboratorio de Servicios a la Industria y al Sistema Científico (UNLP-CIC-CONICET), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 esq. 115, 1900 La Plata, Argentina b CEQUINOR (UNLP-CONICET), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 esq. 115, 1900 La Plata, Argentina c Departamento de Farmacia, Facultad de Química Farmacéutica, Universidad de Antioquia, calle 67 No Medellín, Colombia d Departamento de Ciencias Básicas, Universidad Nacional de Luján, Rutas 5 y 7, 6700 Luján, Argentina e Lehrstuhl für Anorganische Chemie I—Bioanorganische Chemie, Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Universitätsstrasse150, D-44801 Bochum, Germany |
| Abstract: | We report a simple and suitable method for the preparation of useful 2-trifluoromethylchromones in one step, in high yields and avoiding the use of solvents. We were able to detect the intermediate of this reaction. Furthermore a mechanism for the formation of the 7-methoxy-3-trifluoroacetyl-2-trifluoromethylchromone through the unexpected double trifluoroacetylation of 4-methoxy-2-hydroxyacetophenone followed by dehydration is also proposed. All compounds are fully identified and characterized by spectroscopic techniques. |
| Keywords: | 2-Trifluoromethylchromones NMR characterization One-pot synthesis |
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