Z-Selective intramolecular Horner-Wadsworth-Emmons reaction for the synthesis of macrocyclic alkenes |
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| Authors: | Kaori Ando Kaori Sato |
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| Institution: | Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido 1-1, Gifu 501-1193, Japan |
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| Abstract: | The Z-selective intramolecular Horner-Wadsworth-Emmons reaction of the substrates 7-12 (RO)2P(O)CHR′CO2Et (R′ = (CH2)nCHO) (R = Ph or o-tBuC6H4) gives the 13-18-membered cyclic alkenes selectively (up to Z:E = 97:3) in good yields using NaH in THF under high dilution conditions. |
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