Recent advances in annulations enabled by nucleophilic Lewis base/metal dual catalysis |
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| Institution: | 1. College of Chemistry, Green Catalysis Center, Zhengzhou University, Zhengzhou 450001, China;2. School of Science, Henan Agricultural University, Zhengzhou 450002, China;1. Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China;2. Department of Chemistry, Taiyuan Normal University, Jinzhong 030619, China;3. Department of Electronic Science, Xiamen University, Xiamen 361005, China;1. Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China;2. College of Public Health, Zhengzhou University, Zhengzhou 450001, China;1. Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China;2. School of Chemistry and Chemical Engineering, The Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Shihezi 832004, China;3. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Lanzhou 730000, China |
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| Abstract: | Metal/nucleophilic Lewis base dual catalysis has been recognized as a reliable and promising strategy for finishing ideal organic synthesis over the past decades. The new strategy can usually achieve some chemical reactions that cannot be realized by the traditionally mono-catalytic system, dramatically expanding the synthetic utility of chemical transformations by leveraging additional activation modes. Thus considerable progress has been made in the synthesis of a wide range of heterocyclic and biologically active compounds by using the combination of diversely metal/nucleophilic Lewis base dual catalysts, including metal/phosphine, metal/N-heterocyclic carbene (NHC) and metal/tertiary amine dual catalysis systems. In this review, we describe a comprehensive and updated advance of metal/nucleophilic Lewis base dual catalytic annualtion reactions, meanwhile, the related mechanism and the application of these annulation strategies in natural product total synthesis will be highlighted in detail. |
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