Macrocyclic supramolecular biomaterials in anti-cancer therapeutics |
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| Institution: | 1. Department of Chemistry, School of Physical Sciences, Mizoram University, Aizawl, Mizoram 796004, India;2. Department of Industrial Chemistry, School of Physical Sciences, Mizoram University, Aizawl, Mizoram 796004, India;1. Science and Technology on Thermostructural Composite Materials Laboratory, School of Materials Science and Engineering, Northwestern Polytechnical University, Xi''an 710072, China;2. Key Laboratory of Aerosol Chemistry and Physics, State Key Laboratory of Loess and Quaternary Geology (SKLLQG), Institute of Earth Environment, Chinese Academy of Sciences, Xi''an 710061, China;3. Center of Excellence in Quaternary Science and Global Change, Chinese Academy of Sciences, Xi''an 710061, China;4. University of Chinese Academy of Sciences, Beijing 100049, China;5. Department of Environmental Science and Engineering, Xi''an Jiaotong University, Xi''an 710049, China;1. School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China;2. National Center for Nanoscience and Technology, Beijing 100190, China;3. Artemisinin Research Center, Institute of Chinese Materia Medica, Beijing 100700, China;1. School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China;2. School of Innovation and Entrepreneurship, Shaoguan University, Shaoguan 512005, China;1. College of Nuclear Science and Technology, Harbin Engineering University, Harbin 150001, China;2. Laboratory of Nuclear Energy Chemistry, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;3. China Institute of Atomic Energy, Beijing 102413, China;4. State Key Laboratory of Nuclear Resources and Environment, School of Nuclear Science and Technology, East China University of Technology, Nanchang 330013, China;5. School of Chemistry, University of the Punjab, Lahore 54590, Pakistan |
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| Abstract: | Macrocyclic supramolecular complexes demonstrate the dynamic potential to solve global biomedical challenges, a promising cancer treatment modality. The macrocyclic system is an important heterocyclic system widely present in natural products and synthetic molecules. The unique structural feature of macrocyclic supramolecular complexes with desirable donor & acceptor characteristics is beneficial for readily binding with various enzymes and receptors in biological systems through diverse weak interactions, thereby exhibiting broad bioactivities. Macrocyclic-related research and macrocyclic molecules-based medicinal chemistry developments have become rapidly developing areas of study. Numerous macrocyclic-based molecules as clinical drugs have been extensively used in the clinic to treat various diseases with high therapeutic potency. This critically analyzed work systematically reviews current developments of macrocyclic supramolecular complexes-based compounds in the range of medicinal chemistry as anticancer, anti-inflammatory, and other therapeutic agents, together with their potential applications in diagnostics and pathology. This review will be helpful for medicinal chemistry researchers to develop new thoughts in the quest for rational designs of more active and less toxic macrocyclic supramolecular complexes-based medicinal drugs, as well as more effective diagnostic agents and pathologic probes. |
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