On-line preconcentration and determination of chromium in parenteral solutions by inductively coupled plasma optical emission spectrometry |
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| Affiliation: | 1. Chemistry Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata – 700032, India;2. Molecular Parasitology Laboratory, Infectious Diseases & Immunology Division, CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata – 700032, India;3. Chemistry Division, Sir Padampat Singhania University, Udaipur, Rajasthan, India;4. Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700032, India;1. Center for Water Resource Cycle Research, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea;2. Center for Environment, Health and Welfare Research, Cellular and Molecular Toxicology Laboratory, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea;3. Department of Bioresources and Rural System Engineering, Hankyong National University, Anseong, Republic of Korea;4. Environmental Engineering Program, Department of Civil Engineering, 238 Harbert Engineering Center, Auburn University, Auburn, AL 36849, USA;5. Environmental Functional Materials & Biocolloids Laboratory, Seoul National University, Seoul 151-921, Republic of Korea;6. Department of Energy and Environmental Engineering, Korea University of Science and Technology (UST), Daejeon 305-350, Republic of Korea;1. Department of Chemical Engineering and Technology, Indian Institute of Technology-Banaras Hindu University (IIT-BHU), Varanasi, Uttar Pradesh, India;2. Department of Food and Nutritional Sciences, University of Reading, Reading, United Kingdom |
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| Abstract: | A method for the preconcentration and speciation of chromium was developed. On-line preconcentration and determination were obtained using inductively coupled plasma optical emission spectrometry (ICP-OES) coupled with flow injection. To determinate the chromium (III) present in parenteral solutions, chromium was retained on activated carbon at pH 5.0. On the other hand, a step of reduction was necessary in order to determine total chromium content. The Cr(VI) concentration was then determined by difference between the total chromium concentration and that of Cr(III). A sensitivity enrichment factor of 70-fold was obtained with respect to the chromium determination by ICP-OES without preconcentration. The detection limit for the preconcentration of 25 ml of sample was 29 ng l−1. The precision for the 10 replicate determinations at the 5 μg l−1 Cr level was 2.3% relative standard deviation, calculated with the peak heights. The calibration graph using the preconcentration method for chromium species was linear with a correlation coefficient of 0.9995 at levels near the detection limits up to at least 60 μg l−1. The method can be applied to the determination and speciation of chromium in parenteral solutions. |
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