Therapeutic poly(amino acid)s as drug carriers for cancer therapy |
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| Institution: | 1. School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China;2. Department of Cardiology, The Affiliated TCM Hospital of Guangzhou Medical University, Guangzhou 510120, China;3. Bioscience and Biomedical Engineering Thrust, The Hong Kong University of Science and Technology (Guangzhou), Guangzhou 511400, China;4. Division of Life Science, Hong Kong University of Science and Technology, Hong Kong 999077, China;1. Hospital of Stomatology, Jilin University, Changchun 130021, China;2. School of Materials Science and Engineering, Hainan University, Haikou 570228, China;3. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China;4. School of Stomatology, China Medical University, Shenyang 110001, China;5. Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China;1. State Key Lab of Fine Chemicals, School of Chemical Engineering, Liaoning Key Lab for Energy Materials and Chemical Engineering, Dalian University of Technology, Dalian 116024, China;2. College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China;1. College of Chemistry and Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding 071002, China;2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, China;3. Department of Chemistry, The University of Manchester, Manchester M13 9PL, United Kingdom;1. School of Chemistry and Chemical Engineering, Shihezi University/State Key Laboratory Incubation Base for Green Processing of Chemical Engineering, Shihezi 832000, China;2. State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China;1. College of Physics and Center of Quantum Materials and Devices, Chongqing University, Chongqing 401331, China;2. College of Material Science and Engineering, Chongqing University, Chongqing 400044, China;3. Beijing Key Laboratory of Microstructure and Property of Advanced Materials, Beijing University of Technology, Beijing 100024, China;1. Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education, Hohai University, Nanjing 210098, China;2. College of Environment, Hohai University, Nanjing 210098, China;3. State Key Laboratory of Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Tongji University, Shanghai 200092, China |
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| Abstract: | As one of the top global health problems, the effective treatment of cancer is one of the most urgent clinical challenges. Currently, the main treatments for cancer include surgery, chemotherapy, radiotherapy, and gene therapy etc. Chemotherapy is one of the most commonly used treatments, however it has limitations such as highly toxic side effects and low drug utilization rate that limit its application. Gene therapy, as an emerging cancer treatment, has limitations such as drug instability, off-target effects and low internalization efficiency. Poly(amino acid)s carriers with good biocompatibility, degradability and multifunctionality as drug carriers have received much attention, as they can reduce the toxic side effects of chemotherapy, improve drug utilization, and enhance the internalization efficiency and utilization of gene drugs. However, little attention has been paid to the nature of the carriers themselves. This paper reviews the immunomodulatory, anti-inflammatory, antioxidant, internalization-promoting and apoptosis-promoting functions of poly(amino acid)s drug carriers in tumor therapy to provide a theoretical basis for different carrier-drug-adapted synergistic therapies. |
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