CAR-T cells for cancer immunotherapy |
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| Institution: | 1. School of Pharmacy, China Pharmaceutical University, Nanjing 210000, China;2. School of Science, China Pharmaceutical University, Nanjing 210000, China;3. Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China;1. School of Nursing, Shanghai Jiao Tong University, Shanghai, China;2. Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Chicago, Chicago IL, United States;3. Center for Circadian and Sleep Medicine, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States;4. Division of Endocrinology, Diabetes and Metabolism, University of Illinois at Chicago, Chicago, IL, United States;1. College of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China;2. College of Public Health, Shanxi Medical University, Taiyuan 030001, China;3. School of Basic Medical Science, Health Science Center, Xi''an Jiaotong University, Xi''an 710061, China;4. School of Public Health, Health Science Center, Xi''an Jiaotong University, Xi''an 710061, China;5. College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu 611130, China |
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| Abstract: | Adoptive immunotherapy expressing synthetic chimeric antigen receptors (CAR) on T cells through in vitro modifications represents a new and innovative strategy in cancer treatment. This new approach enables T cells to recognize and bind tumor antigens via a single-chain variable fragment recognition domain, circumventing the restriction of major histocompatibility complex. This review summarized the structure/design of CAR-T cells and the evolution process this technology went through, displaying the theoretical foundation for CAR-T therapy, the marketed products and the latest preclinical and clinical research progress. Finally, we provided perspectives on this technology's development and potential future applications, especially for treating hematological malignant and solid tumors. |
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