Synthesis,insecticidal activity and stability study of novel nitromethylene neonicotinoids with five-membered aromatic heterocycles |
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| Institution: | 1. Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;2. Shanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China;1. School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China;2. Teaching and Experiment Centre, Sun Yat-sen University, Shenzhen 518107, China;3. Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China;4. College of Chemistry and Environmental Science, Hebei University, Affiliated Hospital of Hebei University, Baoding 071002, China;1. Department of Chemistry, University of Science and Technology of China, Hefei 230026, China;2. School of Food and Biological Engineering, Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, Hefei University of Technology, Hefei 230009, China;1. College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China;2. Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China;3. Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Twenty-four novel neonicotinoid analogues with nitromethylene and five-membered aromatic heterocycles were designed and synthesized. All target molecular structures have been confirmed by analytical and spectral data. Some compounds exhibited notable insecticidal activities against aphid (Aphis medicaginis) and brown planthopper (Nilaparvata lugens). The aqueous stability test confirmed that the stabilities of those compounds were superior to the leading compound, and the photostability was even better than that of imidacloprid. |
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