Synthesis and immunological evaluation of Mincle ligands-based antitumor vaccines |
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| Institution: | 1. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, College of Life Sciences and KLMDASR of Tianjin, Nankai University, Tianjin 300353, China;2. School of Chemistry, Tiangong University, Tianjin 300387, China;1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China;2. State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China;1. Department of Environmental Science and Engineering, Xi''an Jiaotong University, Xi''an 710049, China;2. Research Institute of Xi''an Jiaotong University, Hangzhou 311200, China;1. State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, China;2. School of Mechanical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;1. School of Chemistry and Chemical Engineering, Shanghai Engineering Technology Research Center for Pharmaceutical Intelligent Equipment, Shanghai Frontiers Science Research Center for Druggability of Cardiovascular Noncoding RNA, Institute for Frontier Medical Technology, Shanghai University of Engineering Science, Shanghai 201620, China;2. Affiliated Sixth People''s Hospital, Shanghai JiaoTong University, Shanghai 200233, China;3. Trauma Center, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201620, China |
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| Abstract: | The development of novel adjuvants constitutes a new strategy for the research of tumor vaccines. Immunomodulatory molecule adjuvants are one of the novel adjuvants that can effectively stimulate the pattern recognition receptors to activate the downstream pathways of immune cells. However, there are few studies on immunomodulatory molecular adjuvants associated with C-type lectin. It has been reported that GlcC14C18 is a Mincle ligand with a relatively simple structure and strong adjuvant activity in vivo. Herein, we coupled GlcC14C18 with MUC1 glycopeptide and evaluated its immune effect. In addition, we also synthesized α-GlcC14C18-MUC1 and β-GlcC14C18-MUC1 based on the two configurations of GlcC14C18 and compared their immune effects. The results show that both of the two configurations of the vaccine have a good immune effect, but to a certain extent, the immune effect of β-GlcC14C18-MUC1 is better than that of α-GlcC14C18-MUC1. |
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