Hydrogel-mediated drug delivery for treating stroke |
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| Affiliation: | 1. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China;2. Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou 450001, China;3. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001, China;1. College of Medical Imaging, Shanxi Medical University, Taiyuan 030001, China;2. College of Public Health, Shanxi Medical University, Taiyuan 030001, China;3. School of Basic Medical Science, Health Science Center, Xi''an Jiaotong University, Xi''an 710061, China;4. School of Public Health, Health Science Center, Xi''an Jiaotong University, Xi''an 710061, China;5. College of Chemistry and Life Science, Sichuan Provincial Key Laboratory for Structural Optimization and Application of Functional Molecules, Chengdu Normal University, Chengdu 611130, China;1. School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China;2. Department of Chemistry, Maynooth University, National University of Ireland, Maynooth, Co. Kildare, Ireland;3. State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China |
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| Abstract: | Stroke is a common disease and is the major cause of death and disability. It occurs and generates devastating neurological deficits when cerebral blood vessel is blocked (ischemic stroke, IS) or ruptured (hemorrhagic stroke, HS). Hydrogel, being biodegradable and biocompatible, have shown attractive advantages in stroke therapy as a new biomaterial with desirable mechanical properties and tunability of structure, owing to special ability to load different cargoes for multiple treatment strategies, such as pharmacotherapy based on drug-delivery systems and cell therapy including mesenchymal stem cells (MSCs) and neural progenitor cells (NPCs) for improving functional outcomes. However, a comprehensive review of the functional hydrogel for treatment of stroke is still lacking. Therefore, in this work, the main pathological mechanisms of stroke including IS and HS are comprehensively described. The benefits of hydrogel for stroke treatment are also summarized regarding the natural advantages and the delivery advantages. Simultaneously, the application development of hydrogel for treatment of stroke is highlighted. Finally, the unique considerations and challenges in the design and application of hydrogel is discussed for treatment of stroke and clinical application in the future. |
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