|
|||||
|
|
Oxytrifluoromethylation of multiple bonds using copper catalyst under mild conditions |
|
| Authors: | Hiromichi Egami Ryo Shimizu Mikiko Sodeoka |
| Affiliation: | a RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan b Sodeoka Live Cell Chemistry Project, ERATO, Japan Science and Technology Agency, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan c Graduate School of Science and Engineering, Saitama University, 255 Shimo-okubo, Sakura-ku, Saitama 338-8570, Japan |
| Abstract: | Oxytrifluoromethylation reaction of styrene derivatives and alkynes with external and internal oxygen nucleophiles, catalyzed by copper (I) salts under mild conditions, was developed. Direct formation of a β-trifluoromethylstyrene derivative from a styrene derivative was also achieved by the reaction in the presence of a Brønsted acid. Further transformation of the oxytrifluoromethylated products was conducted to demonstrate their utility. |
| Keywords: | Trifluoromethylation Copper Olefin Alkyne Togni reagent |
| 本文献已被 ScienceDirect 等数据库收录！ | |