糖尿病患者红细胞镁和蛋白酪氨酸磷酸酶的关系

目的探讨了糖尿病患者红细胞镁、蛋白酪氨酸磷酸酶(PTP)和血糖的关系．方法用葡萄糖氧化酶法和放免法分别测定30例糖尿病患者(DM)和20例正常对照组(NT)空腹血糖(FGP)胰岛素浓度(FINS)，等离子体原子发射光谱法测定红细胞镁，酶联免疫法测定红细胞胞浆PTP活性．结果DM组年龄，体重和体重指数(BMI)与NT组相比无显著性；年龄(岁)(57．33±7．21)vs(58．35±7．71)；体重(kg)(61．00±8．29)vs(61．95±6．96)；BMI(kg．m-2)(23．50±2．50)vs(23．40±2．70)；收缩压(kPa)(16．41±0．95vs(16．76±0．98)；舒张压(kPa)(9．96±0．66)vs(10．28±0．73)，DM组FGP和PTP活性显著高于NT组(FGP(mmol-L-1)(10．03±2．01)vs(5．16±0．70)，P<0．001；PTP活性(U)(8．40±1．99)vs(6．17±2．84)，P<0．05)；DM组红细胞镁显著低于NT组(Mg(μmo1．g-1)(5．48±0．66)vs(6．47±0．63)，P<0．001)．相关分析显示红细胞镁与PTP活性呈显著负相关(γ=-0．58，P<0．01)，PTP活性与空腹血糖呈显著正相关(γ=0．81，P<0．01)．结论红细胞内低镁和高PTP活性与糖尿病患者高血糖状态密切相关．

Relationship between Erythrocyte Magnesium and Protein Tyrosine Phosphatase in Diabetes Mellitus

Objective: The relationship among erythrocyte magnesium, fasting plasma glucose and PTP in diabetes mellitus is analyzed. Methods: Thirty patients with diabetes and tweenty health subjects are studied. The erythrocyte magnesium concentrations. fasting plasma glucose(FPG), fasting plasma insulin(FINS) and activity of erythrocyte PTP are measured. Results: show that erythrocyte magnesium is lower in diabetic subjects than controls(p<0.001), FGP and PTP activity are higher in diabetic subjects than controls(p<0.001, p<0.05,respectively) .Interestingly, there is significantly negative correlation between erythrocyte magnesium and PTP activity(r = -0.58,P, 0.01) .In addition, there is a significantly positive relationship between FPG and mp activity(r=0.81, p<0.01). Conclusion: Reduced erythrocyte magnesium and increased PTP activity contribute to high glucose in diabetic subjects.