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| P(AA-co-DMAA)/SA互穿水凝胶的制备及对盐酸小檗碱的释放 | |
| 引用本文： | 王娜娜,林松柏,王克平,柯爱茹,王立华.P(AA-co-DMAA)/SA互穿水凝胶的制备及对盐酸小檗碱的释放[J].厦门大学学报(自然科学版),2011,50(Z1):84-86. |
| 作者姓名： | 王娜娜 林松柏 王克平 柯爱茹 王立华 |
| 作者单位： | 1. 华侨大学材料科学与工程学院,福建 厦门 361021;黎明职业大学轻纺工程系,福建 泉州 362000 2. 黎明职业大学轻纺工程系,福建 泉州 362000;黎明职业大学轻纺工程系,福建 泉州 362000 3. 华侨大学材料科学与工程学院,福建 厦门,361021 4. 黎明职业大学轻纺工程系,福建 泉州,362000 |
| 基金项目： | 福建省自然科学基金，福建省教育厅科技项目，泉州市科技重大专项 |
| 摘 要： | 先采用泡沫分散聚合法,以丙烯酸(AA)和N,N-二甲基丙烯酰胺(DMAA)为单体制备超孔P(AA-co-DMAA)凝胶,再以戊二醛为交联剂,将海藻酸钠(SA)作为第二网络互穿到P(AA-co-DMAA)网络中,制得P(AA-co-DMAA)/SA互穿网络水凝胶,研究其对盐酸小檗碱的释放行为.结果表明,载药凝胶在pH=6.8溶液中对盐酸小檗碱具有缓释效果,升高温度使凝胶对盐酸小檗碱的累计释放率增大,增大戊二醛和SA的用量使累计释放率降低. |
| 关 键 词： | 互穿水凝胶 盐酸小檗碱 释放 |
Synthesis and Release Properties on Berberine Hydrochloride of P(AA-co-DMAA)/SA Interpenetrating Polymer Networks Hydrogels |
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| WANG Na-na,LIN Song-bai,WANG Ke-ping,KE Ai-ru,WANG Li-hua.Synthesis and Release Properties on Berberine Hydrochloride of P(AA-co-DMAA)/SA Interpenetrating Polymer Networks Hydrogels[J].Journal of Xiamen University(Natural Science),2011,50(Z1):84-86. | |
| Authors: | WANG Na-na LIN Song-bai WANG Ke-ping KE Ai-ru WANG Li-hua |
| Institution: | WANG Na-na1,LIN Song-bai1,2,WANG Ke-ping1,KE Ai-ru2,WANG Li-hua1(1.College of Material Science and Engeneering,Huaqiao University,Xiamen 361021,China,2.Department of Light Industry & Textile Engineering,Liming Vocational University,Quanzhou 362000,China) |
| Abstract: | The superporous hydrogels P(AA-co-DMAA) are synthesized by dispersion polymerization in foam state with acrylic acid(AA) and N,N-dimethyl acrylamide(DMAA) as monomers,then preparing P(AA-co-DMAA)/SA interpenetrating polymer networks(IPN) hydrogels with glutaric dialdehyde as crosslinking agent,sodium alginate(SA) as a second network.Release behavior of the hydrogels on berberine hydrochloride was studied.The results show that the loaded-drug hydrogels have a sustained-release on berberine hydrochloride in p... |
| Keywords: | interpenetrating polymer networks hydrogel berberine hydrochloride release |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |