Rhodium catalyzed 1,4-conjugate addition of 1,5-azastibocines with electron deficient olefins |
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Authors: | Kakusawa Naoki Kurita Jyoji |
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Institution: | Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan. |
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Abstract: | The rhodium-catalyzed reaction of Sb-aryl-1,5-azastibocines with alpha,beta-unsaturated ketones and esters is described. Exclusive formation of 1,4-conjugate adduct was achieved in aqueous NMP (N-methyl-2-pyrrolidinone) in the presence of 5 mol% of RhCl(cod)](2), and no formation of Heck adduct was observed in this condition. Reactions with various enones and enoates were also demonstrated to prove generality of the 1,4-conjugate addition. |
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