Synthesis and antiviral activity of 4H-[1,2,5]oxadiazolo-[3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides |
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Authors: | Jing Bo Shi Jing Gaoc Ya Ping Wangd Qi Zheng Yao a School of Pharmacy China Pharmaceutical University Nanjing China b School of Pharmacy Anhui Medical University Hefei China c School of Pharmaceutical Science Jiangsu University Zhenjiang China d Zhaoke Pharmaceutical Company Limited Hefei China |
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Affiliation: | a School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;b School of Pharmacy, Anhui Medical University, Hefei 230032, China;c School of Pharmaceutical Science, Jiangsu University, Zhenjiang 212013, China;d Zhaoke Pharmaceutical Company Limited, Hefei 230088, China |
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Abstract: | A series of 4H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxide nucleosides was designed,synthesized and evaluated against vesicular stomatitis virus(VSV)in Wish cell.The antiviral activities of all compounds were stronger than those of acyclovir,while their toxicities were similar to those of acyclovir. |
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Keywords: | Oxadiazolo[3,4-d]pyrimidine nucleoside Antivirus Synthesis |
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