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Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice |
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| Authors: | Brian Spencer Robert A Marr Edward Rockenstein Leslie Crews Anthony Adame Rewati Potkar Christina Patrick Fred H Gage Inder M Verma Eliezer Masliah |
| Institution: | (1) Department of Neurosciences, University of California San Diego, 92093 La olla, California, USA;(2) Department of Pathology, University of California San Diego, 92093 La Jolla, California, USA;(3) Department of Neuroscience, Rosalind Franklin University of Medicine and Sciences, 60064 North Chicago, IL, USA;(4) Laboratory of Genetics, The Salk Institute for Biological Studies, 92037 La Jolla, California, USA |
| Abstract: | BackgroundProteolytic degradation has emerged as a key pathway involved in controlling levels of the Alzheimer's disease (AD)-associated amyloid-β (Aβ) peptide in the brain. The endopeptidase, neprilysin, has been implicated as a major Aβ degrading enzyme in mice and humans. Previous short and intermediate term studies have shown the potential therapeutic application of neprilysin by delivering this enzyme into the brain of APP transgenic mice using gene transfer with viral vectors. However the effects of long-term neprilysin gene transfer on other aspects of Aβ associated pathology have not been explored yet in APP transgenic mice. |
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