Synthesis and study of some new N-substituted imide derivatives as potential antibacterial agents |
| |
| Authors: | Abd El-Galil M. Khalil Moged A. Berghot Moustafa A. Gouda |
| |
| Affiliation: | (1) Department of Pharmaceutical Microbiology, Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland;(2) Department of Medical Chemistry, Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland;(3) Department of Antibiotics and Microbiology, National Medicines Institute, 00-725 Warsaw, Poland;(4) Department of Biomedical Science and Technology, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, Cagliari, Italy |
| |
| Abstract: | Dibenzobarrelene (I) was used as a starting compound for the synthesis of some new 3a,4,9,9a-tetrahydro-4,9-[1,2]benzeno-1H-benzo[f]isoindole-1,3(2H)-diones, N-substituted with: 4-toluenesulfonyloxy, III; butoxy, IV; 3-bromopropoxy, V; 3-(4-phenylpiperazin-1-yl)propoxy, VI; 3-chloro-3-oxopropyl, VIII; 3-(4-phenylpiperazin-1-yl)-3-oxopropyl, IXa; 3-(4-methylpiperazin-1-yl)-3-oxopropyl, IXb; 3-oxo-3-(piperidin-1-yl)propyl, X; 3-morpholino-3-oxopropyl, XI; 3-phenylamino-3-oxopropyl, XII; 2-acetylaminoethyl, XIV; 2-aminoethyl, XV, and 2-acetoxyethyl, XVI. Newly synthesized compounds were characterized by IR, 1H and 13C NMR, and mass spectral data. Selected products were tested for antimicrobial activity. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
