Synthesis of phenol-class azo derivatives of 4-aminosalicylic acid |
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Authors: | Shi Fei Sheng Hui Xia Zheng Jiang Liu Zheng Bao Zhao |
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Affiliation: | a School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China;b First Clinical College, Shanxi Medical University, Taiyuan 030001, China |
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Abstract: | To explore the better prodrug of 4-aminosalicylic acid (4-ASA) with higher activity and less side effects against the inflammatory bowel disease.4-ASA,after a succession of synthesis process,was conjugated with various carrier molecules to get seven azo derivatives of 4-ASA.All compounds were characterized by FT-IR,1H NMR,13C NMR spectras in detail.New derivatives of 4-ASA were definituded. |
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Keywords: | 4-Aminosalicylic acid Azo derivatives of 4-aminosalicylic acid Inflammatory bowel disease |
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