四川轮环藤根中两种海岛轮环藤-N-氧化物的分离鉴定

从中国特有植物四川轮环藤(Cyclea sutchuenensis Gagnep.)根中分得两种海岛轮环藤碱-N-氧化物。采用波谱分析和化学方法鉴定, 证明分别为海岛轮环藤碱-2β-N-氧化物(3)和海岛轮环藤碱-2'β-N-氧化物(4)。二者均为新生物碱, 是首尾氧桥双苄基异喹啉生物碱-N-氧化物。从该植物根中还分得已知的海岛轮环藤碱(1)和海岛轮环藤酚碱(2)。本文首次详细报道并分析了2的1^H NMR和13^C NMR数据。经三种人癌细胞实验, 证明2具有显著的抗癌活性。

Two novel insularine-N-oxides from the roots of cyclea sutchuenensis gagnep

Two novel insularine-N-oxides, insularine-2b-N-oxide (I) and insularine-2'b-N-oxide (II), were isolated along with insularine and insulanoline from the roots of C. sutchuenensis indigenous only to China. Their structures have been elucidated on the basis of spectral anal. and confirmed by chem. correlation with insularine. Both I and II are rare examples of naturally occurring head-to-tail bisbenzylisoquinoline N-oxides. Additional, the 1H and 13C NMR spectral data of insulanoline were first reported and assigned in detail. Insulanoline showed significant inhibitory activity against human colon adenocarcinoma.