N-substituted hydroxyureas as urease inhibitors |
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| Authors: | Uesato Shinichi Hashimoto Yuichiro Nishino Masaru Nagaoka Yasuo Kuwajima Hiroshi |
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| Institution: | Department of Biotechnology, Faculty of Engineering, Kansai Univeristy, Suita, Osaka, Japan. uesato@ipcku.kansai-u.ac.jp |
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| Abstract: | In order to seek a urease inhibitor more potent than hydroxyurea (1), its alkyl- or phenyl-substituted derivatives were synthesized and evaluated for their effect on the jack bean urease. Of 16 compounds tested, m-methyl- (10) and m-methoxy-phenyl substituted hydroxyurea (13) showed the most potent inhibitory activities against the enzyme. |
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