Synthesis of 3-aryl-2-[hydroxy(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines |
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| Authors: | L. A. Shemchuk V. P. Chernykh D. V. Levashov K. M. Sytnik L. M. Shemchuk |
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| Affiliation: | 1.National Pharmaceutical University,Kharkov,Ukraine |
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| Abstract: | By heating arylamides of N-ethoxalylanthranilic acid in the acetic acid mediun in the presence of triethylamine the corresponding ethyl 3-aryl-4-oxo-3,4-dihydroquinazoline-2-carboxylates were obtained. The latter in the conditions of the Grignard reaction formed 3-aryl-2-[hydroxy-(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines. |
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