Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding |
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| Authors: | Khan Abid Silversides Jon D Madden Leigh Greenman John Archibald Stephen J |
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| Affiliation: | Department of Chemistry and Institute of Clinical Biosciences, The University of Hull, Cottingham Road, Hull, UK HU6 7RX. |
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| Abstract: | The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state. |
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