Stereoselective synthesis of the cytotoxic macrolide FD-891 |
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Authors: | García-Fortanet Jorge Murga Juan Carda Miguel Marco J Alberto |
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Affiliation: | Departamento de Química Inorganica y Organica, Universitat Jaume I, Castellón, Spain. |
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Abstract: | [reaction: see text] A total synthesis of the naturally occurring, cytotoxic macrolide FD-891 is described. Three fragments were first stereoselectively constructed using mainly asymmetric aldol and allylation reactions. The complete framework was then assembled using two Julia-Kocienski olefinations to connect the three fragments and a Yamaguchi reaction to close the macrolactone ring. |
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