| Chemistry or biology: which comes first after the genome is sequenced? |
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| 作者姓名： | King RW |
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| 摘 要： |
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Chemistry or biology: which comes first after the genome is sequenced? |
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| King RW.Chemistry or biology: which comes first after the genome is sequenced?[J].Chemistry & Biology,1999,6(12):R327-R333. |
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| Authors: | King R W |
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| Institution: | Institute of Chemistry and Cell Biology, Harvard Medical School, Boston, MA 02115, USA. randy_king@hms.harvard.edu |
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| Abstract: | In drug discovery, chemical screening is performed after a protein's function has been determined. By screening for ligands that alter the function of a cell or an organism, new proteins that participate in poorly understood biological processes can be identified. Genomic and expression-cloning technologies can rapidly identify the protein targets of these ligands, enhancing the power of chemical screening as a tool for the initial stages of biological discovery. |
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