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Nitrogen oxide generation during reduction of nitrofuran antibacterial drugs
Authors:N. B. Grigor'ev  G. V. Chechekin  A. P. Arzamaztsev  V. I. Levina  V. G. Granik
Abstract:Proof of the nitrogen oxide generation during the chemical reduction of a series of nitrofuran derivatives is obtained by polarographic detection of the nitroprusside anion. A hypothesis is made about the mechanism of the peroxynitrite anion formation, which is responsible for the biological activity of nitrofurans during the course of their reduction.Russian Federation State Scientific Center NIOPIK, Moscow 103787, Russia. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 902–906, July, 1999.
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