Synthesis and Biological Study of Some 4-oxo-Thiazolidine Derivatives of 2-Aminothiazole |
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Authors: | Pushkal Samadhiya Ritu Sharma Santosh K Srivastava Savitri D Srivastava |
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Institution: | Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H.S. Gour University (A Central University), Sagar, M.P., 470003 India |
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Abstract: | Conventional and microwave assisted synthesis of new series of N‐2‐{2‐(substituted phenyl)‐4‐oxo‐5‐(substituted benzylidene)‐1,3‐thiazolidine}‐iminoethyl]‐2‐aminothiazole 5a–5m have been developed. The cycloaddition reaction of thioglycolic acid with N‐{2‐(substituted benzylidenehydrazino)‐ethyl}‐2‐aminothiazole 3a–3m in the presence of anhydrous ZnCl2 afforded new heterocyclic compounds N‐2‐{2‐(substituted phenyl)‐4‐oxo‐1,3‐thiazolidine}‐iminoethyl]‐2‐aminothiazole 4a–4m . The later product on treatment with several selected substituted aromatic aldehydes in the presence of C2H5ONa undergoes Knoevenagel reaction to yield 5a–5m . The structures of compounds 1 , 2 , 3a–3m , 4a–4m and 5a–5m were confirmed by IR, 1H NMR, 13C NMR, FAB‐Mass and chemical analysis. All above compounds were screened for their antimicrobial activities against some selected bacteria and fungi and antituberculosis study against M. tuberculosis. |
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Keywords: | conventional microwave synthesis 2‐aminothiazole 4‐oxo‐thiazolidine antimicrobial antitubercular |
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