c-di-GMP displays a monovalent metal ion-dependent polymorphism |
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Authors: | Zhang Zhaoying Gaffney Barbara L Jones Roger A |
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Institution: | Department of Chemistry and Chemical Biology, 610 Taylor Road, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA. |
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Abstract: | Cyclic diguanosine monophosphate (c-di-GMP) is known to be an important signaling molecule that regulates the formation of bacterial biofilms. We demonstrate here by UV, CD, and NMR that it displays a surprising polymorphism that varies with the monovalent counterion and is consistent with the formation of a G-quartet structure in K+ and a stacked structure in Li+ or Na+. The ability of this rigid molecule to adopt different alignments may be important to its biological role. |
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