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Direct incorporation of A 6α(7α)-formamido group into penicillins and cephalosporins
Authors:Michael J Pearson
Institution:Beecham Pharmaceuticals, Research Division, Brockham Park, Betchworth, Surrey, RH3 7AJ Great Britain
Abstract:6β(7β)-(N-2,2,2-Trichloroethoxycarbonyl-N-trifluoromethanesulphonylamino) penicillins and cephalosporins have been converted into the corresponding 6α(7α)-formamido-6β(7β)-2,2,2-trichloroethoxycarbonylamino derivatives, by treatment with N,N-bis(trimethylsilyl) formamide and triethylamine.
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