Synthesis of c27-substituted ecdysteroids,potential tools for biochemical studies |
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| Authors: | D Guédin-Vuong Y Nakatani B Luu G Ourisson |
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| Institution: | Laboratoire de Chimie Organique des Substances Naturelles, associé au CNRS, Université Louis Pasteur, Centre de Neurochimie, 5 rue Blaise Pascal, 67084 Strasbourg, France |
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| Abstract: | A sequence of selective protection procedures is described, facilitating the efficient cleavage of the ecdysteroid side-chain, which can then be reconstructed; in this way, C-27 ether-linked analogues of ecdysteroids have been synthesized, one of which displays highly significant biological activities. |
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