An improved entry to a key intermediate for thienamycin synthesis from methyl (<span class="math"><math><mtext>R</mtext></math></span>)-3-hydroxybutanoate via direct epimerization at C-3 on 2-azetidinone rings期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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An improved entry to a key intermediate for thienamycin synthesis from methyl ( $R$ )-3-hydroxybutanoate via direct epimerization at C-3 on 2-azetidinone rings

Authors:	Toshiyuki Chiba Takeshi Nakai

Institution:	Department of Chemical Technology, Tokyo Institute of Technology, Meguro-ku, Tokyo 152, Japan

Abstract:	An improved entry to a key thienamycin intermediate is described which relies upon the direct epimerization at C-3 of the 3-(1-hydroxyethyl)-2-azetidinone derivatives readily obtained from methyl ( $R$ )-3-hydroxybutanoate.

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