Syntheses of PGJ2 type analogues: 16-hydroxy-11-oxo-Δ5,9,12,14-prostatetraenoic acid t-butyl ester and its related derivatives

PGJ₂ analogues, the title compound ($\text{8c}$) and its related derivatives ($\text{8a}$, $\text{8b}$), were synthesized $\text{via}$ the three-component coupling process involving 1,4-addition reaction of phenylsulfinylallylic carbanion ($\text{2}$′) to cyclopentenone derivative ($\text{1}$) followed by trapping the generated enolate with aldehyde ($\text{3}$).