A route to prostaglandin precursors from 1-(phenylthio)-2-octenyllithium. |
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Authors: | Malcolm R. Binns Richard K. Haynes Dale E. Lambert Paul A. Schober |
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Affiliation: | Department of Organic Chemistry, University of Sydney, Sydney NSW 2006, Australia |
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Abstract: | The enolates generated by the conjugate addition of 1-(phenylthio)-2-octenyllithium to 4--butoxycyclopent-2-en-1-one and <-crotonolactone react with methyl 7-halohept-5-ynoates in the presence of Ph3SnCl to deliver products which may be converted into prostaglandin precursors. |
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